Hidden weakness makes prostate cancer self-destruct

Researchers have discovered that prostate cancer depends on two key enzymes, PDIA1 and PDIA5, to survive and resist therapy. When blocked, these enzymes cause the androgen receptor to collapse, killing cancer cells and enhancing the effects of drugs like enzalutamide. They also disrupt the cancer’s energy system, striking it on multiple fronts. This breakthrough could open a new path to overcoming drug resistance in advanced prostate cancer.

Health Nov 11, 2025 0 20 Add to Reading List

Hidden weakness makes prostate cancer self-destruct

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WHY THE HEN DOES NOT HAVE TEETH STORY BOOK

Click the image to get your copy!

WHY THE HEN DOES NOT HAVE TEETH STORY BOOK

Click the image to get your copy!

Researchers have discovered that prostate cancer depends on two key enzymes, PDIA1 and PDIA5, to survive and resist therapy. When blocked, these enzymes cause the androgen receptor to collapse, killing cancer cells and enhancing the effects of drugs like enzalutamide. They also disrupt the cancer’s energy system, striking it on multiple fronts. This breakthrough could open a new path to overcoming drug resistance in advanced prostate cancer.

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